Which class of local anesthetics is metabolized by pseudocholinesterase?

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Multiple Choice

Which class of local anesthetics is metabolized by pseudocholinesterase?

Explanation:
Esters are metabolized by plasma pseudocholinesterase. Pseudocholinesterase rapidly hydrolyzes ester-type local anesthetics in the bloodstream, inactivating them quickly. This results in a shorter duration of action for ester LAs compared with amide LAs, which are mainly metabolized in the liver by amidases and the cytochrome P450 system. If a patient has pseudocholinesterase deficiency, ester anesthetics can last longer. The other categories aren’t described by this metabolic pathway.

Esters are metabolized by plasma pseudocholinesterase. Pseudocholinesterase rapidly hydrolyzes ester-type local anesthetics in the bloodstream, inactivating them quickly. This results in a shorter duration of action for ester LAs compared with amide LAs, which are mainly metabolized in the liver by amidases and the cytochrome P450 system. If a patient has pseudocholinesterase deficiency, ester anesthetics can last longer. The other categories aren’t described by this metabolic pathway.

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